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KMID : 0363220100480040296
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Korean Journal of Dermatology
2010 Volume.48 No. 4 p.296 ~ p.299
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A Case of Guttate Psoriasis after Treatment with IFN-α
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Kim Jung-Eun
Lee Sung-Yul
Kim Hyung-Dong
Park Young-Lip
Lee Jong-Suk
Whang Kyu-Uang
Kim Dae-Hyun
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Abstract
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Psoriasis is considered to be an autoimmune disease of abnormal keratinocyte proliferation induced by T lymphocytes. An association with several cytokines has been suggested. Interferon (IFN) is a cytokine secreted by virus-infected cells and has the ability to prevent further infection of cells that were exposed to it. It has therefore been used as a therapeutic agent for many chronic viral diseases such as chronic hepatitis C. Recently, however, IFN has also been considered to be a triggering factor in the development of psoriasis. We describe an 18-year-old woman presenting with guttate psoriasis, who suffered soft tissue sarcoma and underwent chemotherapy containing IFN-α. This is possibly the first case of guttate psoriasis associated with IFN-α in the Korean literature.
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KEYWORD
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Guttate psoriasis, Interferon alpha
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